Mechanosensitivity Is a Characteristic Feature of Cultured Suburothelial Interstitial Cells of the Human Bladder

Mechanosensitivity Is a Characteristic Feature of Cultured Suburothelial Interstitial Cells of the Human Bladder

Bladder dysfunction is characterised by urgency, frequency (pollakisuria, nocturia), and dysuria and should result in urinary incontinence. Most of those signs may be attributed to disturbed bladder sensitivity. There’s rising proof that, moreover the urothelium, suburothelial interstitial cells (suICs) are concerned in bladder afferent sign processing.

The large growth of the bladder throughout the filling section implicates mechanical stress delivered to the entire bladder wall. Little is understood concerning the response of suICs upon mechanical stress. Due to this fact, we investigated the results of mechanical stimulation in cultured human suICs. We used fura-2 calcium imaging as a serious physiological readout. We discovered spontaneous intracellular calcium exercise in 75 % of the aesthetic suICs. Outlined native stress software by way of a glass micropipette led to native elevated calcium exercise in all stimulated suICs, spreading over the entire cell.

A complete of 51% of the neighboring cells in a radius of as much as 100 µm from the stimulated cell confirmed an elevated exercise. Hypotonic ringer and shear stress additionally induced calcium transients. We discovered an 18-times enhance in syncytial exercise in comparison with unstimulated controls, leading to an amplification of the first calcium sign elicited in single cells by 50%.

Our outcomes converse in favor of a excessive sensitivity of suICs for mechanical stress and help the view of a practical syncytium between suICs, which may amplify and distribute native stimuli. Earlier research of connexin expression within the human bladder recommend that this mechanism is also related in regular and pathological operate of the bladder in vivo.

 

Totally Built-in Time-Gated 3D Fluorescence Imager for Deep Neural Imaging

This paper presents a tool for time-gated fluorescence imaging within the deep mind, consisting of two on-chip laser diodes and 512 single-photon avalanche diodes (SPADs). The sting-emitting laser diodes ship fluorescence excitation above the SPAD array, parallel to the imager. Within the time area, laser diode illumination is pulsed and the SPAD is time-gated, permitting a fluorescence excitation rejection as much as O.D. three at 1 ns of time-gate delay.

Every SPAD array is masked with Talbot gratings to allow the mapping of 2D array photon counts right into a 3D picture. The 3D picture achieves a decision of 40, 35, and 73 m within the x, y, z instructions, respectively, in a noiseless atmosphere, with a most body price of 50 kilo-frames-per-second. We current measurement outcomes of the spatial and temporal profiles of the dual-pulsed laser diode illumination and of the photon detection traits of the SPAD array. Lastly, we present the imager’s means to resolve a glass micropipette full of purple fluorescent microspheres. The system’s 420 m-wide cross part permits it to be inserted at arbitrary depths of the mind whereas reaching a subject of view 4 occasions bigger than fiber endoscopes of equal diameter.

Cytoskeleton consists of greater than 100 proteins and represents a dynamic community of the mobile cytoplasm. Cytoskeletal features embrace spatial group of mobile parts, structural connection of the cell with exterior atmosphere, and biomechanical power era. Cytoskeleton takes half, at totally different ranges, in all phases of platelet biogenesis: megakaryocyte (MK) differentiation, MK maturation, and platelet formation. As well as, it additionally performs a serious function in every stage of platelet operate.

Inherited platelet problems (IPDs) are a bunch of uncommon illnesses featured by low platelet rely and/or impaired platelet operate.

 Mechanosensitivity Is a Characteristic Feature of Cultured Suburothelial Interstitial Cells of the Human Bladder
Mechanosensitivity Is a Characteristic Feature of Cultured Suburothelial Interstitial Cells of the Human Bladder

Sublethal mechanical shear stress will increase the elastic shear modulus of purple blood cells however doesn’t change capillary transit velocity

Blood publicity to supraphysiological shear stress inside mechanical circulatory help is suspected of lowering purple blood cell (RBC) deformability and being primal within the pathogenesis of a number of secondary problems. No prior works have explored RBC dynamics with the decision required to find out shear elastic modulus, and/or cell capillary velocity, following publicity to mechanical stresses. Wholesome RBCs had been uncovered to 0,5,50, and 100Pa in a Couette shearing system.

For comparability, blood was additionally uncovered to warmth therapy – a technique that predictably will increase RBC rigidity. Shear modulus evaluation required aspiration of single RBCs by way of slender micropipettes at identified suction power. Cell transit velocities had been measured inside micro-channels in areas of fully-developed move. Supraphysiological shear stress elevated the elastic shear modulus by 39% and 69% following publicity to 50 and 100Pa, respectively.

Cell transit velocity, nevertheless, didn’t change following shear, with concurrent decreases in cell quantity probably nullifying elevated shear modulus-friction interactions. Variations noticed had been according to our inner management (warmth therapy), supporting that cell mechanics are considerably impaired following supraphysiological-sublethal shear publicity.

AXYPET 20-200UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4

AP-8-200-ALT 1/pk
EUR 547.2
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 20-200UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10

AP-8-200-STD 1/pk
EUR 608.4
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 50-300UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4

AP-8-300-ALT 1/pk
EUR 547.2
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 50-300UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10

AP-8-300-STD 1/pk
EUR 608.4
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 5-50UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4

AP-8-50-ALT 1/pk
EUR 547.2
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 5-50UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10

AP-8-50-STD 1/pk
EUR 608.4
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

Jade Smart? Mix

M1113-500
EUR 529.2

Individual Reaction Mix 8

G065-8 200 reactions
EUR 200.4

Human IL-8 Recombinant Protein

R00423-8 5ug/vial
EUR 310.8
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Human IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

AXYGEN® AXYPET® PRO 0.5-10 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE

AP-8-10-P 1/pk
EUR 546
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYGEN® AXYPET® PRO 20-200 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE

AP-8-200-P 1/pk
EUR 546
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYGEN® AXYPET® PRO 30-300 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE

AP-8-300-P 1/pk
EUR 546
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYGEN® AXYPET® PRO 5-50 ΜL, 8 CHANNEL PIPETTOR, AUTOCLAVABLE

AP-8-50-P 1/pk
EUR 546
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

Smart Personal Micro Centrifuge

abx725002-1Unit 1 Unit
EUR 622.8

Jade Smart? Mix-iCycler

M1114-500
EUR 529.2

Jade Smart? Mix-ROX

M1116-500
EUR 529.2

Pe Filter For Micropipette Protection

DD061968 PK100
EUR 101.46

8-channel reagent reservoir

DD316010 PK100
EUR 323.76

Brand 8 Channel Manifold

BR704526-1EA EACH
EUR 10.6

Pesticide Mix 8 Containing 15 Compounds in Acetonitrile

SPXPR-8 1ML
EUR 249.66

8 mm Crimp head ; Level 3 High Performance Applications

ECMJ-8 EACH
EUR 295.26

Jade Smart? Mix-Low ROX

M1115-500
EUR 529.2

Human THSD7a ELISA kit

8-E01A2155
  • EUR 1524.00
  • EUR 624.00
  • EUR 822.00
  • 192 tests
  • 1 plate of 48 wells
  • 1 plate of 96 wells
Description: A competitive ELISA for quantitative measurement of Human THSD7a in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

HandEvac 8-Channel plastic aspirator

ARG1290 EACH
EUR 224.58

0.5-10uL Lambda 8-Channel

PIP0308 EACH
EUR 579.12

5-50uL Lambda 8-Channel

PIP0346 EACH
EUR 579.12

20-200uL Lambda 8-Channel

PIP0348 EACH
EUR 579.12

30-300uL Lambda 8-Channel

PIP0352 EACH
EUR 591.66

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

DLR-8-OHdG-Ge-48T 48T
EUR 562.8
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

DLR-8-OHdG-Ge-96T 96T
EUR 729.6
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.

Nucleic Acid Instrument

Smart-32 1 unit/set Ask for price

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

RD-8-OHdG-Ge-48Tests 48 Tests
EUR 560.4

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

RD-8-OHdG-Ge-96Tests 96 Tests
EUR 775.2

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

RDR-8-OHdG-Ge-48Tests 48 Tests
EUR 585.6

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

RDR-8-OHdG-Ge-96Tests 96 Tests
EUR 811.2

pAAV-DJ/8 Vector

VPK-420-DJ-8 10 µg
EUR 776.4
Description: The pAAV-DJ/8 vector contains the rep and cap genes required to generated recombinant AAV of serotype DJ/8. Co-transfect with other packaging plasmids and an expression vector into 293 cells for AAV-DJ/8 packaging.

Arium Smart Station UP Water - Benchtop

WAT4340 EACH
EUR 2143.2

Arium Smart Station Pure Water - Benchtop

WAT4344 EACH
EUR 1824

Micropipette Acura 825 0.1-2 uL Socorex

DD61104 EACH
EUR 340.86

Micropipette Acura 825 2-20 uL Socorex

DD61107 EACH
EUR 313.5

Micropipette Acura 825 20-200 uL Socorex

DD61110 EACH
EUR 313.5

Micropipette Acura 825 100-1000 uL Socorex

DD61111 EACH
EUR 313.5

Micropipette Acura 835 1-10 uL Socorex

DD61113 EACH
EUR 339.72

N.8 Nom Kine/Dyna Viscosity Density Std

REVIS-N-8 500ML
EUR 190.38

Transmembrane Channel Like 8 (TMC8) Antibody

abx027907-400ul 400 ul
EUR 627.6

Transmembrane Channel Like 8 (TMC8) Antibody

abx027907-80l 80 µl
EUR 343.2

Transmembrane Channel Like 8 (TMC8) Antibody

20-abx219015
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Transmembrane Channel Like 8 (TMC8) Antibody

20-abx329114
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Costar Disposable 8-Channel Reservoir Sterile

4878 PK100
EUR 220.02

HandEvac 8-Channel Stainless Steel Adapter

ARG1284 EACH
EUR 141.36

Eppendorf Xplorer 8 Channel 0.5-10ul

E4861000104 EACH
EUR 929.1

Eppendorf Xplorer 8 Channel 50-1200ul

E4861000163 EACH
EUR 929.1

Tacta Pipette 8 Channel 0.5-10ul

PIP9728 EACH
EUR 878.94

Tacta Pipette 8 Channel 5-100ul

PIP9730 EACH
EUR 878.94

Tacta Pipette 8 Channel 30-300ul

PIP9732 EACH
EUR 878.94

Handevac Handheld Aspirator 8-Channel A

Z688193-1EA EACH
EUR 161.88

Smart 2X PCR pre-mix Pfu (30ul)

9K-002-0038 30uL, 30uL
EUR 697.37

SMART Standard tube dispensing cassette 5-pack

DIS0118 EACH
EUR 3749.46

Arium Smart Station UP Water - Wall Mounted

WAT4342 EACH
EUR 2143.2

Arium Smart Station Pure Water - Wall Mounted

WAT4346 EACH
EUR 1824

ASPIR-8, 5ml reservoir for 8-channel pipettes, individually wrapped

P7005-1S 100/pack
EUR 119.94
Description: ASPIR-8 5ml reservoir for 8-channel pipettes

ASPIR-8, 25ml reservoir for 8-channel pipettes, individually wrapped

P7025-1S 100/pack
EUR 119.94
Description: ASPIR-8 25ml reservoir for 8-channel pipettes

ASPIR-8, 10ml reservoir for 8-channel pipettes, individually wrapped

P8010-1S 100/pack
EUR 119.94
Description: ASPIR-8 10ml reservoir for 8-channel pipettes

PSA (Prostate-specific antigen) ELISA test

8 96T/Box Ask for price
Description: ELISA based test for quantitative detection of PSA (Prostate-specific antigen)

MicroCrystal Mount Assortment, box of 20; Model #8, on 18mm rods

M4-L18SP-8 20 MOUNTS
EUR 125
Description: MicroCrystal Mount Assortment, box of 20; Model #8, on 18mm rods

PIPETTOR,8 CHANNEL,20-200UL,1 EA

4888 1/pk
EUR 1018.8
Description: Corning Liquid Handling Equipment; Costar 8 Pette and 12 Pette Multichannel Pipettors

ELISA Microplate Washer Head (8 channel) replacement

MPW-WH-1 1
EUR 424.8

8 Channel Adapter kit for FA-2

ASP1106 EACH
EUR 72.96

Eppendorf Xplorer 8 Channel Pipette 15-300ul

E4861000147 EACH
EUR 929.1

Xplorer plus 8-channel 5-100ul yellow

E4861000783 EACH
EUR 1120.62

Xplorer plus 8-channel 15-300ul orange

E4861000805 EACH
EUR 1120.62

Xplorer plus 8-channel 50-1200ul green

E4861000821 EACH
EUR 1120.62

EPPENDORF(R) XPLORER(R) 8-CHANNEL PIPET

EP4861000120-1EA EACH
EUR 901.74

Axypet Pro 0.5-10uL 8-Channel Pipettor

PIP2724 EACH
EUR 619.02

Axypet Pro 5-50uL 8-Channel Pipettor

PIP2726 EACH
EUR 619.02

Axypet Pro 20-200uL 8-Channel Pipettor

PIP2728 EACH
EUR 619.02

Axypet Pro 30-300uL 8-Channel Pipettor

PIP2730 EACH
EUR 619.02

AAV-DJ/8 Helper Free Packaging System

VPK-400-DJ-8 1 kit
EUR 1166.4
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ/8 Helper Free Expression System

VPK-410-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

scAAV-DJ/8 Helper Free Expression System

VPK-430-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

ASPIR-8, 5ml reservoir for 8-channel pipettes, 5/sterile bag

P7005-5S 200/pack
EUR 139.38
Description: ASPIR-8 5ml reservoir for 8-channel pipettes

ASPIR-8, 25ml reservoir for 8-channel pipettes, 5/sterile bag

P7025-5S 200/pack
EUR 139.38
Description: ASPIR-8 25ml reservoir for 8-channel pipettes

ASPIR-8, 10ml reservoir for 8-channel pipettes, 5/sterile bag

P8010-5S 200/pack
EUR 139.38
Description: ASPIR-8 10ml reservoir for 8-channel pipettes

AAV-DJ/8 Helper Free Promoterless Expression System

VPK-411-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

SMART 2 small tube plastic tip dispensing cassette

DIS0122 EACH
EUR 3756.3

SMART 2 small tube metal tip dispensing cassette

DIS0126 EACH
EUR 3756.3

SMART 2 standard tube dispensing cassette 5-pack

DIS0130 EACH
EUR 3756.3

General 8-Epi Prostaglandin F2 Alpha (8-epi-PGF2a) ELISA Kit

RD-8-epi-PGF2a-Ge-48Tests 48 Tests
EUR 560.4

General 8-Epi Prostaglandin F2 Alpha (8-epi-PGF2a) ELISA Kit

RD-8-epi-PGF2a-Ge-96Tests 96 Tests
EUR 775.2

AAV-DJ/8 Helper Free Bicistronic Expression System (Puro)

VPK-415-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Neo)

VPK-416-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Hygro)

VPK-417-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (GFP)

VPK-418-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Blasticidin)

VPK-419-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

IC Multi Elem (8) Cation Std in 0.005% HNO3

IC-LGC-8-100 100ML
EUR 235.98

AXYGEN® 8-WELL COMB FOR USE WITH 10 CM GEL BOX, 1.0 MM THICKNESS

HGB10-8-1 1/pk
EUR 70.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 8-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.0 MM THICKNESS

HGB15-8-1 1/pk
EUR 82.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 8-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-8-15 1/pk
EUR 82.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 8-WELL COMB FOR USE WITH 7 CM GEL BOX, 0.75 MM THICKNESS

HGB7-8-075 1/pk
EUR 64.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 8-WELL COMB FOR USE WITH 7 CM GEL BOX, 1.0 MM THICKNESS

HGB7-8-1 1/pk
EUR 64.8
Description: Lab Equipment; Axygen Branded EQ

ASPIR-8, 5ml reservoir for 8-channel pipettes, non-sterile, bulk pack

P7005 300/pack
EUR 129.66
Description: ASPIR-8 5ml reservoir for 8-channel pipettes

ASPIR-8, 25ml reservoir for 8-channel pipettes, non-sterile, bulk pack

P7025 100/pack
EUR 95.64
Description: ASPIR-8 25ml reservoir for 8-channel pipettes

ASPIR-8, 10ml reservoir for 8-channel pipettes, non-sterile, bulk pack

P8010 300/pack
EUR 129.66
Description: ASPIR-8 10ml reservoir for 8-channel pipettes

LAMBDA PLUS PIPETTOR 8 CHANNEL,1 TO 10UL

4080 1/pk
EUR 510
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

LAMBDA PLUS PIPETTOR 8 CHANNEL,5 TO 50UL

4081 1/pk
EUR 510
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

LAMBDA PLUS PIPETTOR 8 CHANNEL,20 TO 200UL

4082 1/pk
EUR 510
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

LAMBDA PLUS PIPETTOR 8 CHANNEL,50 TO 300UL

4083 1/pk
EUR 510
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

ProPette LE 8-Channel Pipette, 1 to 10µL

P5208-10 1/pack
EUR 383.2
Description: ProPette LE 8-Channel Pipette 1 to 10µL

ProPette LE 8-Channel Pipette, 2 to 20µL

P5208-20 1/pack
EUR 383.2
Description: ProPette LE 8-Channel Pipette 2 to 20µL

ProPette LE 8-Channel Pipette, 20 to 200µL

P5208-200 1/pack
EUR 383.2
Description: ProPette LE 8-Channel Pipette 20 to 200µL

ProPette LE 8-Channel Pipette, 30 to 300µL

P5208-300 1/pack
EUR 383.2
Description: ProPette LE 8-Channel Pipette 30 to 300µL

ProPette LE 8-Channel Pipette, 5 to 50µL

P5208-50 1/pack
EUR 383.2
Description: ProPette LE 8-Channel Pipette 5 to 50µL

8-Channel Adapter for the Costar Vacuum Aspirator

4931 EACH
EUR 262.2

Eppendorf Research Plus Pipettor 0.5-10ul 8 Channel

E3122000019 EACH
EUR 792.3

Eppendorf Research Plus Pipettor 10-100ul 8 Channel

E3122000035 EACH
EUR 792.3

Eppendorf Research Plus Pipettor 30-300ul 8 Channel

E3122000051 EACH
EUR 792.3

Eppendorf Research Plus Pipettor 0.5-10ul 8 Channel

E3125000010 EACH
EUR 792.3

Eppendorf Research Plus Pipettor 10-100ul 8 Channel

E3125000036 EACH
EUR 792.3

Eppendorf Research Plus Pipettor 30-300ul 8 Channel

E3125000052 EACH
EUR 809.4

Eppendorf Xplorer 8 Channel Pipette 5-100 ul

E4861000120 EACH
EUR 929.1

Xplorer plus 8-channel 0.5-10ul medium gray

E4861000767 EACH
EUR 1120.62

SLS Lab Basics 8 Channel Pipette 5 - 50uL

SLS4918 EACH
EUR 648.66

SLS Lab Basics 8 Channel Pipette 10 - 100uL

SLS4920 EACH
EUR 648.66

SLS Lab Basics 8 Channel Pipette 20 - 200uL

SLS4922 EACH
EUR 648.66

SLS Lab Basics 8 Channel Pipette 30 - 300uL

SLS4924 EACH
EUR 648.66

SLS Lab Basics 8 Channel Pipette 0.5 - 10uL

SLS4926 EACH
EUR 648.66

Picus NxT 0.2-10ul 8 channel elec pipette

PIP3906 EACH
EUR 1402.2

Picus NxT 5-120ul 8 channel elec pipette

PIP3907 EACH
EUR 1402.2

Picus NxT 10-300ul 8 channel elec pipette

PIP3908 EACH
EUR 1402.2

Picus NxT 50-1200ul 8 channel elec pipette

PIP3909 EACH
EUR 1402.2

Pipetman L Multi 8 Channel Pipette 2-20ul

FA10009 EACH
EUR 853.86

WHATMAN(R) 850-DS 8-CHANNEL FILTER PLATE

WHA77073300 PK50
EUR 501.6

MINI TUBE, 8 STRIP, POLYPROPYLENE, 1.1 ML, CLEAR, NONSTERILE, BULK

MTS-11-8-C 120/pk
EUR 168
Description: Deep Well/Assay Plates - Axygen; Assay/Other - Axygen

SMART Small tube plastic tip dispensing cassette 5-pack

DIS0108 EACH
EUR 3749.46

SMART Small tube metal tip dispensing cassette 5-pack

DIS0112 EACH
EUR 3749.46

CORNING 5-50 µL LAMBDA ELITETOUCH 8 CHANNEL PIPETTOR

6058 1/pk
EUR 546
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

CORNING 20-200 µL LAMBDA ELITETOUCH 8 CHANNEL PIPETTOR

6059 1/pk
EUR 546
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

CORNING 30-300 µL LAMBDA ELITETOUCH 8 CHANNEL PIPETTOR

6060 1/pk
EUR 546
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

MULTICHANNEL PIPETTE STAND FOR 8 OR 12 CHANNEL PIPETTORS

4088 1/pk
EUR 68.4
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

Voltage-Dependent Calcium Channel Gamma-8 Subunit (CACNG8) Antibody

20-abx148797
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Sodium Channel Protein Type 8 Subunit Alpha (SCN8A) Antibody

20-abx135926
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Sodium Channel Protein Type 8 Subunit Alpha (SCN8A) Antibody

20-abx321273
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Sodium Channel Protein Type 8 Subunit Alpha (SCN8A) Antibody

20-abx322781
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

TRANSTAR DISPOSABLE RESERVOIR LINER,8-CHANNEL,NS,BK100/100

94878 100/pk
EUR 318
Description: Corning Liquid Handling Equipment; Transtar

8 channel ph/ec/sal/tds/res/ion meter

C3060 ea
EUR 1944

8 channel ph/ec/sal/tds/res/do meter

C3062 ea
EUR 1944

Mouse Transmembrane channel- like protein 8, Tmc8 ELISA KIT

ELI-51686m 96 Tests
EUR 1038

Human Transmembrane channel- like protein 8, TMC8 ELISA KIT

ELI-36423h 96 Tests
EUR 988.8

8-Channel Manifold for Accuris SmartWasher 96 Microplate Washer

MIC9604 EACH
EUR 368.22

Pipetman L Multi 8 Channel Pipette 0.5ul to 10ul

FA10013 EACH
EUR 853.86

Pipetman L Multi 8 Channel Pipette 20ul to 300ul

FA10015 EACH
EUR 853.86

Given mechanical circulatory help operates at shear stresses according to the current research, it’s believable that these units induce elementary impairment to the fabric properties of RBCs.

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